Creating Hobo Casserole with Ground Beef & Potatoes can be straightforward if you follow these essential steps:

1. Preheat Oven: Preheat your oven to 350°F (175°C).
2. Prepare Casserole Dish: Grease a 9×13 inch baking dish with cooking spray or olive oil.
3. Cook Ground Beef: In a skillet over medium heat, brown the ground beef until fully cooked. Drain excess fat and set aside.
4. Sauté Onions: In the same skillet, add diced onions and sauté until translucent.
5. Combine Ingredients: In a large mixing bowl, combine the cooked beef, sautéed onions, cream of mushroom soup, milk, garlic powder, onion powder, and a pinch of salt and pepper. Mix well.
6. Layer the Casserole: Place half of the sliced potatoes at the bottom of the prepared baking dish. Spread half of the mixed vegetables over the potatoes.
7. Add Meat Mixture: Pour half of the meat mixture over the vegetables and potatoes evenly.
8. Repeat Layers: Repeat the layers with the remaining potatoes, mixed vegetables, and meat mixture.
9. Top with Cheese: Finally, sprinkle shredded cheddar cheese evenly over the top layer.
10. Cover and Bake: Cover the dish with aluminum foil and bake for 45 minutes.
11. Uncover and Finish Baking: After 45 minutes, uncover and bake for an additional 15-20 minutes, or until the potatoes are tender and the cheese is bubbly and golden.
12. Cool and Serve: Allow the casserole to cool for a few minutes before serving.

These steps will guide you in creating this incredible Hobo Casserole effortlessly.